Cook the Orzo: Bring a pot of salted water to a boil. Cook orzo according to package directions, then drain and set aside.

Brown the Beef: In a large, oven-safe skillet over medium-high heat, cook ground beef until browned and crumbly. Drain any excess grease. Sprinkle with the seasoned salt, garlic powder, and onion powder; stir to combine.

Make the Sauce: To the skillet with the beef, add the dill relish, yellow mustard, tomato sauce, heavy cream, Worcestershire sauce, and 1 cup of the shredded cheddar cheese. Stir everything together and bring to a gentle simmer, allowing the cheese to melt and the sauce to become creamy.

Combine with Orzo: Add the drained orzo to the skillet and mix well until evenly coated. Sprinkle the remaining 1 cup of cheddar cheese evenly over the top.

Finish and Serve: Place the skillet in a preheated 350 degree F (175 degree C) oven for 5 to 10 minutes, or cover and cook on the stovetop over low heat, until the cheese on top is melted and bubbly. Scoop onto plates and serve hot.